Your body produces waste and toxins every day – it’s part of being alive. Removing these toxins from your systems is crucial to your longevity. Several amino acids are involved in the body’s detoxifying processes, helping to remove harmful substances in the liver, kidneys, and elsewhere.

SUPREMEplex™ is rich in these detoxifying amino acids, ridding the body of everything from ammonia and heavy metals to free radicals and other harmful substances.

L-arginine, for example, is central to detoxifying ammonia. The body produces ammonia as a byproduct of protein metabolism. It is highly toxic to cells, especially the brain. Converting this harmful substance to urea is the principal function of the liver, from where it’s safely transported to the kidney to be excreted in the urine.

Glutamic acid detoxifies the body in a different way. It is a precursor to glutathione, a powerful antioxidant. Free radicals are generated via metabolism or external sources such as pollution, UV radiation, and smoking. If left to accumulate, they cause oxidative stress – associated with inflammation, ageing, and several chronic diseases. Antioxidants like glutathione neutralize free radicals, preventing everything from DNA degradation to organ damage.

Lastly, there’s histidine and serine. Histidine helps with heavy metal detoxification. Metallothionein is a family of proteins designed to remove metals like cadmium, mercury, arsenic, and lead. Alongside cysteine, histidine is required for its formation. Meanwhile, serine forms several molecules that contribute to detoxification pathways, such as phospholipids and sphingolipids.

These amino acids team up to boost your body’s natural detox power, helping keep things in balance and taking some of the load off your organs. With SUPREMEplex™, you’re giving your body extra support to tackle everyday toxins and stay resilient against environmental stressors.

References

1. Averill-Bates DA. The antioxidant glutathione. InVitamins and hormones 2023 Jan 1 (Vol. 121, pp. 109-141). Academic Press.
2. Marí M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxidants & redox signaling. 2009 Nov 1;11(11):2685-700.
3. Pedrazini MC, Martinez EF, dos Santos VA, Groppo FC. L-arginine: its role in human physiology, in some diseases and mainly in viral multiplication as a narrative literature review. Future Journal of Pharmaceutical Sciences. 2024 Dec;10(1):1-8.
4. Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ. De novo sphingolipid biosynthesis necessitates detoxification in cancer cells. Cell reports. 2022 Sep 27;40(13).
5. Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Z, Li Y. Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nature Immunology. 2023 Jan;24(1):162-73.
6. Thirumoorthy N, Kumar KM, Sundar AS, Panayappan L, Chatterjee M. Metallothionein: an overview. World journal of gastroenterology: WJG. 2007 Feb 2;13(7):993.
7. Won JS, Singh I. Sphingolipid signaling and redox regulation. Free Radical Biology and Medicine. 2006 Jun 1;40(11):1875-88.